Sportal.co.nz 02.Oct.2012Getty Images
The 25-year-old centre, who was absent from the Boks' 31-8 thumping of Australia, will undergo surgery on Wednesday for an ankle injury which will see him sidelined for three months.
His demise means the All Blacks can expect to face the midfield combination of captain Jean de Villiers at No.12 and last week's debutant Jaco Taute outside him.
"Frans has quite a few loose pieces of bone in his ankle and every now and then one of them gets lodged in the joint, causing him excruciating pain," team doctor Craig Roberts told reporters on Monday.
"As a long-term solution, we're sending him for surgery to have it cleaned out on Wednesday. Unfortunately that means he will be out for three months and he will miss the end-of-year tour."
Meanwhile, fullback Zane Kirchner is also in doubt for the two sides' Championship finale and was a notable absence from training on Tuesday.
After scoring two tries in the rout of the injury-stricken Wallabies, the Bulls custodian bruised his hip while attempting to take down Adam Ashley-Cooper. The latter was knocked out as a result of the sickening collision.
Patrick Lambie is likely to take his place in the starting line-up, however, a final ruling will be made by Thursday.