James Mortimer 28.Feb.2013Getty Images
The two men were instrumental in the Cheetahs 2011 campaign, where they finished exactly one point behind the Crusaders as the most lethal attacking outfit (435 points).
Pretorius' first start of the 2013 Investec Super Rugby season results in Piet van Zyl dropping to the bench.
Experienced Springboks prop Coenie Oosthuizen will play off the bench, with the pine seeing a few changes from the Cheetahs loss to the Sharks last week.
Riaan Smith in for the Elgar Watts, Rynhard Landman replaces Waltie Vermeulen.
Vermeulen will require surgery after damaging his ligaments, resulting in Landman being called up by Cheetahs coaching staff.
Cheetahs: 15 Hennie Daniller, 14 Willie le Roux, 13 Johann Sadie, 12 Robert Ebersohn, 11 Raymond Rhule, 10 Johan Goosen, 9 Sarel Pretorius, 8 Philip van der Walt, 7 Pieter Labuschagne, 6 Frans Viljoen, 5 Francois Uys, 4 Lodewyk de Jager, 3 Lourens Adriaanse, 2 Adriaan Strauss (captain), 1 Trevor Nyakane.
Replacements: 16 Ryno Barnes, 17 Coenie Oosthuizen, 18 Rynhard Landman, 19 Johannes Prinsloo, 20 Piet van Zyl, 21 Riaan Smith, 22 Ryno Benjamin.