First five-eighths Bosch, who had been in outstanding goal-kicking form for the side in the first two rounds of the competition, is going home due to a family bereavement.
Boeta Chamberlain has been named as his replacement, the only change to the Sharks starting line-up from the side that beat the Highlanders last week.
It will be Chamberlain's starting debut for the side after showing some impressive touches in pre-season play.
Sharks coach Sean Everitt told sharksrugby.co.za he was expecting a physical game in Wellington and had named only two backs among his substitutes.
"Preparations for the game on Saturday have gone well and the guys are enjoying Wellington," he said.
"We're hoping for more of the same from last week, if the weather allows it. It looks like it's going to remain the same which is good, and we can then look to unleash our backs again."
Captain and centre Lukhanyo Am said they were expecting full pressure from the Hurricances.
"We know the Hurricanes are a quality side. It's their first game at home this year and they will come out guns blazing.
"We've seen what they can do, winning in Argentina is never easy and they bounced back from the first game when they went down to the Stormers in Cape Town.
"This is a good team, well-balanced that likes to move the ball around and, from our side, we just want to perform," he said.
Am said he was enjoying the captaincy role with the Sharks although he added winning their first two games had made his job as leader much easier.
"The results make it easier, there might be a few questions if we weren't winning, but it's really a happy camp and I'm enjoying working with the boys. The vibe amongst us is really good," he said.
The first win in New Zealand against the Highlanders last week had been enjoyable but work still lay ahead of the side.
"It was a massive performance, I was really happy with how we performed as a group. Obviously, we can improve, but it's still early days, just round two, but from our side we just want to try to improve each week and hopefully we will be consistent," he said.
The side was conscious of their high penalty count, the highest in the competition over the first two weeks, and they had talked about that this week.
"We feel that the tendency of conceding penalties is something we can control. These were penalties based on decision-making, not on our systems and we have spent time working on that this week. We can't afford that kind of penalty count in tighter games because could cost us the game," he said.