Having arrived at their Australian base to prepare for their Test against Australia on September 12, Nienaber said the South Africans were spending the next few days adjusting to their new environment.
"We are excited to be in Australia and to begin our preparations for the away leg of the Rugby Championship," he told South African media.
"The time zone and conditions are different to that which we experienced in South Africa, we getting acclimatised and settled in as quickly as possible will be vital.
"Fortunately, we are allowed training during specific times of the day while we are in quarantine, and we need to make the most of those sessions to ensure that we hit the ground running in our opening Test," he said.
In the two weeks they have to adapt, the Springboks would be looking to use their time wisely to prepare, mentally and physically, for the challenging games ahead in their defence of the Rugby Championship title.
"We are playing against Australia in back-to-back matches on their home patch with supporters in the stadiums, which is something we haven't experienced since the Rugby World Cup final in 2019.
"Then we face the task of playing two Tests in a row against New Zealand. So, we are under no illusions about the challenge that awaits us.
"That said, we have achieved rewarding results so far this season with the structures and systems we have in place, and the sooner we get back into the swing of things, the better prepared we will be when we take to the field," he said.
While they had two weeks in quarantine, the time would be valuable for players to nurse any niggling injuries.
"All of the players should be available for selection for the first Test, so the coaches will be in a good position in terms of squad selection when we begin our preparations for those matches," he said.
South Africa's director of rugby, Rassie Erasmus, is not with the side, although he may join them later.