Caelan Doris will captain the side, which includes three New Zealanders, halfback Jamison Gibson-Park, second five-eighths Bundee Aki and wing James Lowe, all of whom were part of Farrell's British & Irish Lions side in Australia earlier in the year.
Farrell said when announcing the squad, "We're playing four top-quality southern hemisphere teams who are all coming off the back of a busy block of matches of late, and they'll be keen to finish their year strongly.
"First up is New Zealand, and we're excited to get back to Chicago for the Gallaher Cup match.
"I've no doubt the Irish global supporter base will be out once again in force to cheer on the team in a brilliant city at a world-class arena."
After playing the All Blacks, Ireland plays Japan, Australia and South Africa, all in Dublin.
Farrell said, "There's an exciting look to the panel and there's an opportunity for the more experienced players, and for those who made their debuts on the summer tour to Georgia and Portugal.
"The coaching team is looking forward to seeing all of the players take their opportunity over the coming weeks."
Ireland's squad is: (Forwards) Thomas Ahern, Ryan Baird, Finlay Bealham, Tadhg Beirne, Jack Boyle, Thomas Clarkson, Jack Conan, Caelan Doris, Tadhg Furlong, Iain Henderson, Ronan Kelleher, Gus McCarthy, Paddy McCarthy, Andrew Porter, Cian Prendergast, James Ryan, Dan Sheehan, Nick Timoney, Josh van der Flier; (Backs) Bundee Aki, Caolin Blade, Craig Casey, Jack Crowley, Ciaran Frawley, Jamison Gibson-Park, Mack Hansen, Robbie Henshaw, James Lowe, Stuart McCloskey, Tommy O'Brien, Jamie Osborne, Sam Predergast, Gary Ringrose, Jacob Stockdale.
